| Date | Location | Result | |
| November 11 | Wichita Falls, TX | Midwestern State 40, Southwestern Okla. 7 | Box score |
| November 4 | Stephenville, Texas | Midwestern State 44, Tarleton State 23 | Box score |
| October 28 | Tahlequah, OK | Northeastern State 16, Midwestern State 13 | Box score |
| October 21 | Wichita Falls, TX | Midwestern State 58, Southeastern Okla. 7 | Box score |
| October 14 | Wichita Falls, TX | Midwestern State 62, Okla. Panhandle St. 0 | Box score |
| October 7 | Wichita Falls, TX | Midwestern State 20, East Central Univ. 0 | Box score |
| Sept. 30 | Edmond, Okla. | Central Oklahoma 24, Midwestern State 21 | Box score |
| Sep 23, 2000 | Commerce, Texas | Texas A&M-Commerce 27, Midwestern State 10 | Box score |
| September 16 | Blackwater Draw, NM | Midwestern State 33, Eastern New Mexico 16 | Box score |
| September 9 | Wichita Falls, TX | Midwestern State 14, West Texas A&M 7 | Box score |
| August 31 | San Marcos | Southwest Texas St. 34, Midwestern State 13 | Box score |