| Date | Location | Result | |
| Nov 05, 2005 | Wichita Falls, Texas | Midwestern State 35, Abilene Christian 30 | Box score |
| Oct 29, 2005 | Blackwater Draw, NM | Midwestern State 62, Eastern New Mexico 27 | Box score |
| Oct 22, 2005 | Wichita Falls, Texas | Midwestern State 42, East Central 31 | Box score |
| Oct 15, 2005 | Wichita Falls, Texas | Midwestern State 41, Texas A&M-Kingsville 14 | Box score |
| Oct 08, 2005 | Stephenville, Texas | Tarleton State 37, Midwestern State 7 | Box score |
| Oct 01, 2005 | Wichita Falls, Texas | West Texas A&M 47, Midwestern State 44 | Box score |
| Sep 24, 2005 | San Angelo, Texas | Angelo State 30, Midwestern State 29 | Box score |
| Sep 17, 2005 | Wichita Falls, Texas | Midwestern State 24, SE Oklahoma State 17 | Box score |
| Sep 10, 2005 | Commerce, Texas | Texas A&M-Commerce 27, Midwestern State 25 | Box score |
| Sep 03, 2005 | Wichita Falls, Texas | Midwestern State 49, Southwestern Okla. 0 | Box score |