| Date | Location | Result | |
| Dec 04, 2010 | Topeka, Kan. | Washburn 45, Midwestern State 14 | Box score |
| Nov 13, 2010 | Wichita Falls, Texas | Midwestern State 28, Northeastern State 8 | Box score |
| Nov 06, 2010 | Kingsville, Texas | Texas A&M-Kingsville 27, Midwestern State 7 | Box score |
| Oct 30, 2010 | Wichita Falls, Texas | Midwestern State 31, Tarleton State 26 | Box score |
| Oct 23, 2010 | Canyon, Texas | West Texas A&M 42, Midwestern State 29 | Box score |
| Oct 16, 2010 | Wichita Falls, Texas | Midwestern State 35, Angelo State 21 | Box score |
| Oct 09, 2010 | Abilene, Texas | Abilene Christian 31, Midwestern State 28 | Box score |
| Oct 02, 2010 | Wichita Falls, Texas | Midwestern State 38, Incarnate Word 31 | Box score |
| Sep 25, 2010 | Edmond, Okla. | Midwestern State 30, Central Oklahoma 24 | Box score |
| Sep 18, 2010 | Wichita Falls, Texas | Midwestern State 46, Southwestern Okla. 9 | Box score |
| Sep 11, 2010 | Blackwater Draw, NM | Midwestern State 44, Eastern N.M. 17 | Box score |
| Sep 02, 2010 | Las Vegas, NM | Midwestern State 52, New Mexico Highlands 6 | Box score |