| Date | Location | Result | |
| Nov 13, 2021 | Wichita Falls, Texas | Midwestern State 36, Tex. Permian Basin 30 | Box score |
| Nov 06, 2021 | Canyon, Texas | West Tex. A&M 15, Midwestern State 12 | Box score |
| Oct 30, 2021 | Wichita Falls, Texas | Midwestern State 52, Western N.M. 10 | Box score |
| Oct 23, 2021 | Stephenville, Texas | Tarleton St. 17, Midwestern State 14 | Box score |
| Oct 09, 2021 | Wichita Falls, Texas | Midwestern State 30, Tex. A&M-Kingsville 13 | Box score |
| Oct 02, 2021 | Ellensburg, Wash. | Central Washington 30, Midwestern State 20 | Box score |
| Sep 25, 2021 | Wichita Falls, Texas | Midwestern State 31, Eastern NM 24 | Box score |
| Sep 18, 2021 | San Angelo, Texas | Midwestern State 35, Angelo St. 17 | Box score |
| Sep 11, 2021 | Arlington, Texas | Midwestern State 31, Tex. A&M-Commerce 30 | Box score |
| Sep 04, 2021 | Quincy, Ill. | Midwestern State 48, Quincy 27 | Box score |