| Date | Location | Result | |
| 03/13/81 | Kansas City, Mo. | Hillsdale College 65, Midwestern State 64 | Box score |
| 03/11/81 | Kansas City, Mo. | Midwestern State 104, Lincoln Memorial (Tenn.) 87 | Box score |
| 03/10/81 | Kansas City, Mo. | Midwestern State 56, Western New Mexico 55 | Box score |
| 03/04/81 | Wichita Falls, Texas | Midwestern State 78, Wayland Baptist 66 | Box score |
| 03/02/81 | Wichita Falls, Texas | Midwestern State 90, Paul Quinn (Texas) 89 | Box score |
| 02/23/81 | Wichita Falls, Texas | Midwestern State 110, Texas Wesleyan 97 | Box score |
| 02/21/81 | Wichita Falls, Texas | Midwestern State 87, Dallas Baptist 72 | Box score |
| 02/14/81 | Lawton, Okla. | Cameron 93, Midwestern State 82 | Box score |
| 02/10/81 | Plainview, Texas | Midwestern State 70, Wayland Baptist 67 | Box score |
| 02/07/81 | Wichita Falls, Texas | Midwestern State 67, Cameron 66 | Box score |
| 02/04/81 | Wichita Falls, Texas | Midwestern State 91, McMurry 87 | Box score |
| 02/02/81 | Wichita Falls, Texas | Midwestern State 98, Southwestern Okla. 78 | Box score |
| 01/31/81 | Wichita Falls, Texas | Midwestern State 85, Southern Nazarene 83 | Box score |
| 01/29/81 | Hawkins, Texas | Midwestern State 90, Jarvis Christian 82 | Box score |
| 01/26/81 | Wichita Falls, Texas | Midwestern State 95, Wayland Baptist 85 | Box score |
| 01/24/81 | Dallas, Texas | Dallas Baptist 96, Midwestern State 92 | Box score |
| 01/23/81 | Fort Worth, Texas | Texas Wesleyan 96, Midwestern State 88 | Box score |
| 01/17/81 | Oklahoma City, Okla. | Oklahoma Christian 96, Midwestern State 81 | Box score |
| 01/14/81 | Weatherford, Okla. | Southwestern Okla. 78, Midwestern State 76 | Box score |
| 01/10/81 | Lawton, Okla. | Midwestern State 93, Cameron 82 | Box score |
| 01/09/81 | Lawton, Okla. | Midwestern State 75, Southwestern Okla. 72 | Box score |
| 01/08/81 | Lawton, Okla. | Midwestern State 112, Science & Arts Okla. 82 | Box score |
| 01/06/81 | Wichita Falls, Texas | Midwestern State 88, Angelo State 65 | Box score |
| 01/03/81 | Wichita Falls, Texas | Texas State 77, Midwestern State 73 | Box score |
| 01/02/81 | Wichita Falls, Texas | Midwestern State 110, St. Mary's (Texas) 100 | Box score |
| 12/30/80 | Quincy, Ill. | Central Arkansas 84, Midwestern State 72 | Box score |
| 12/29/80 | Quincy, Ill. | Quincy (Ill.) 82, Midwestern State 78 | Box score |
| 12/28/80 | Quincy, Ill. | Midwestern State 71, Augustana (S.D.) 68 | Box score |
| 12/20/80 | Wichita Falls, Texas | Oklahoma Christian 63, Midwestern State 61 | Box score |
| 12/13/80 | San Marcos, Texas | Texas State 96, Midwestern State 55 | Box score |
| 12/12/80 | Nacogdoches, Texas | Stephen F. Austin 75, Midwestern State 56 | Box score |
| 12/09/80 | Abilene, Texas | McMurry 82, Midwestern State 79 | Box score |
| 12/06/80 | Wichita Falls, Texas | Midwestern State 77, Stephen F. Austin 76 | Box score |
| 12/04/80 | Wichita Falls, Texas | Midwestern State 124, Jarvis Christian 90 | Box score |
| 12/02/80 | Laramie, Wyoming | Wyoming 87, Midwestern State 61 | Box score |
| 12/01/80 | Salt Lake City, Utah | Utah 104, Midwestern State 59 | Box score |
| 11/28/80 | Norman, Okla. | Oklahoma 95, Midwestern State 82 | Box score |
| 11/25/80 | Bethany, Okla. | Southern Nazarene 91, Midwestern State 64 | Box score |
| 11/22/80 | San Antonio, Texas | St. Mary's (Texas) 72, Midwestern State 59 | Box score |
| 11/20/80 | Brownwood, Texas | Midwestern State 76, Howard Payne 73 | Box score |
| 11/17/80 | San Angelo, Texas | Midwestern State 68, Angelo State 63 | Box score |
| 11/15/80 | Wichita Falls, Texas | Midwestern State 99, Mary Hardin-Baylor 71 | Box score |
| 11/13/80 | Wichita Falls, Texas | Midwestern State 84, Austin College 76 | Box score |