| Date | Location | Result | |
| 03/05/22 | Frisco, Texas | West Tex. A&M 87, Midwestern State 55 | Box score |
| 03/03/22 | Frisco, Texas | Midwestern State 82, DBU 66 | Box score |
| 03/01/22 | Wichita Falls, Texas | Midwestern State 66, Texas-Tyler 62 | Box score |
| 02/26/22 | Wichita Falls, Texas | Midwestern State 67, Okla. Christian 62 | Box score |
| 02/24/22 | Wichita Falls, Texas | Midwestern State 68, Ark.-Fort Smith 67 | Box score |
| 02/19/22 | Laredo, Texas | Midwestern State 66, Tex. A&M Int'l 61 | Box score |
| 02/17/22 | Kingsville, Texas | Tex. A&M-Kingsville 59, Midwestern State 58 | Box score |
| 02/10/22 | Wichita Falls, Texas | Midwestern State 69, Western NM 50 | Box score |
| 02/08/22 | Wichita Falls, Texas | Midwestern State 75, DBU 61 | Box score |
| 02/05/22 | Portales, NM | Midwestern State 71, Eastern N.M. 49 | Box score |
| 02/03/22 | Lubbock, Texas | Lubbock Christian 66, Midwestern State 52 | Box score |
| 01/29/22 | Wichita Falls, Texas | Midwestern State 79, Cameron 55 | Box score |
| 01/27/22 | Wichita Falls, Texas | Midwestern State 100, West Tex. A&M 90 (OT) | Box score |
| 01/22/22 | Dallas, Texas | DBU 79, Midwestern State 69 | Box score |
| 01/15/22 | Odessa, Texas | Midwestern State 68, Tex. Permian Basin 53 | Box score |
| 01/13/22 | San Angelo, Texas | Angelo St. 75, Midwestern State 73 | Box score |
| 01/08/22 | Wichita Falls, Texas | St. Mary's (TX) 59, Midwestern State 55 | Box score |
| 01/06/22 | Wichita Falls, Texas | Midwestern State 60, St. Edward's 50 | Box score |
| 01/02/22 | Tyler, Texas | Texas-Tyler 69, Midwestern State 68 | Box score |
| 12/31/21 | Commerce, Texas | Tex. A&M-Commerce 82, Midwestern State 70 | Box score |
| 12/16/21 | Wichita Falls, Texas | Tex. A&M-Commerce 73, Midwestern State 48 | Box score |
| 12/13/21 | Wichita Falls, Texas | Texas-Tyler 75, Midwestern State 63 | Box score |
| 12/10/21 | Fort Smith, Ark. | Midwestern State 63, Ark.-Fort Smith 62 | Box score |
| 12/02/21 | Oklahoma City, Okla. | Okla. Christian 72, Midwestern State 64 | Box score |
| 11/30/21 | Lawton, Okla. | Midwestern State 71, Cameron 66 | Box score |
| 11/27/21 | Aberdeen, SD | Minn.-Crookston 68, Midwestern State 60 | Box score |
| 11/26/21 | Aberdeen, SD | Northern St. 84, Midwestern State 70 | Box score |
| 11/22/21 | Canyon, Texas | West Tex. A&M 94, Midwestern State 74 | Box score |
| 11/20/21 | Wichita Falls, Texas | Midwestern State 86, Central Okla. 65 | Box score |
| 11/13/21 | Wichita Falls, Texas | Midwestern State 77, CSU Pueblo 64 | Box score |
| 11/12/21 | Wichita Falls, Texas | UC-Colo. Springs 87, Midwestern State 78 | Box score |