| Date | Location | Result | |
| Nov 4, 2000 | Durant, Okla. | Midwestern St. 3, Southeastern Okla. 0 (15-12,15-9,15-3) | Box score |
| Nov 3, 2000 | Commerce, Texas | A&M-Commerce 3, Midwestern St. 0 (15-12,15-13,15-1) | Box score |
| Nov 1, 2000 | Ft. Worth, Texas | TX Wesleyan 3, Midwestern St. 0 (15-11,15-4,15-10) | Box score |
| Oct 28, 2000 | Wichita Falls, Texas | Central Oklahoma 3, Midwestern St. 0 (15-6,15-11,15-11) | Box score |
| Oct 27, 2000 | Wichita Falls, Texas | Cameron 3, Midwestern St. 0 (15-10,15-6,15-3) | Box score |
| Oct 23, 2000 | Wichita Falls, Texas | Incarnate Word 3, Midwestern St. 1 (15-17,17-15,15-11,15-13) | Box score |
| Oct 21, 2000 | Wichita Falls, Texas | Dallas Baptist 3, Midwestern St. 2 (15-3,15-10,13-15,9-15,15-11) | Box score |
| Oct 20, 2000 | Wichita Falls, Texas | St. Edward's 3, Midwestern St. 0 (15-5,15-12,15-11) | Box score |
| Oct 17, 2000 | Stephenville, Texas | Tarleton St. 3, Midwestern St. 0 (15-10,15-7,15-7) | Box score |
| Oct 11, 2000 | Denton, Texas | Texas Woman's Univ. 3, Midwestern St. 0 (15-7,15-7,16-14) | Box score |
| Oct 7, 2000 | Abilene, Texas | Abilene Christian 3, Midwestern St. 0 (15-7,15-11,15-4) | Box score |
| Oct 7, 2000 | Abilene, Texas | A&M-Kingsville 3, Midwestern St. 0 (15-13,15-9,15-8) | Box score |
| Oct 6, 2000 | Abilene, Texas | West Texas A&M 3, Midwestern St. 0 (15-6,15-9,15-5) | Box score |
| Oct 3, 2000 | Wichita Falls, Texas | Tarleton State 3, Midwestern St. 1 (11-15,15-2,15-8,15-8) | Box score |
| Sep 30, 2000 | Wichita Falls, Texas | A&M-Commerce 3, Midwestern St. 2 (15-11,15-9,10-15,9-15,16-14) | Box score |
| Sep 29, 2000 | Wichita Falls, Texas | Midwestern St. 3, Southeastern Okla. 0 (15-11,15-9,15-6) | Box score |
| Sep 27, 2000 | Dallas, Texas | Dallas Baptist 3, Midwestern St. 1 (14-16,17-15,15-13,15-6) | Box score |
| Sep 23, 2000 | Denton, Texas | Eastern New Mexico 3, Midwestern St. 0 (15-11,15-1,15-11) | Box score |
| Sep 22, 2000 | Denton, Texas | Angelo State Univ. 3, Midwestern St. 0 (15-9,15-6,15-11) | Box score |
| Sep 22, 2000 | Denton, Texas | Tarleton State 3, Midwestern St. 2 (8-15,14-16,15-6,15-6,15-11) | Box score |
| Sep 16, 2000 | Lawton, Okla. | Cameron 3, Midwestern St. 0 (15-13,15-8,15-6) | Box score |
| Sep 15, 2000 | Edmond, Okla. | Central Oklahoma 3, Midwestern St. 0 (15-11,15-3,15-12) | Box score |
| Sep 12, 2000 | Wichita Falls, Texas | TX Wesleyan 3, Midwestern St. 1 (15-3,13-15,15-4,15-13) | Box score |
| Sep 9, 2000 | Austin, Texas | St. Edward's 3, Midwestern St. 1 (14-16,15-11,15-10,15-4) | Box score |
| Sep 9, 2000 | Austin, Texas | St. Mary's Univ. 3, Midwestern St. 0 (15-4,15-10,15-8) | Box score |
| Sep 8, 2000 | Austin, Texas | A&M-Kingsville 3, Midwestern St. 1 (15-8,15-4,4-15,15-11) | Box score |
| Sep 8, 2000 | Austin, Texas | Midwestern St. 3, Ouachita Baptist 1 (15-11,15-8,0-15,15-5) | Box score |
| Sep 6, 2000 | Wichita Falls, Texas | Midwestern St. 3, Texas Woman's Univ. 0 (16-14,17-15,15-12) | Box score |
| Sep 2, 2000 | Kansas City, Mo. | Truman State 3, Midwestern St. 0 (15-3,15-1,15-2) | Box score |
| Sep 2, 2000 | Kansas City, Mo. | Midwestern St. 3, MN-Crookston 0 (15-4,15-7,15-13) | Box score |
| Sep 1, 2000 | Kansas City, Mo. | Rockhurst Univ. 3, Midwestern St. 0 (15-2,15-5,15-2) | Box score |
| Sep 1, 2000 | Kansas City, Mo. | Midwestern St. 3, Pittsburg State 2 (15-6,11-15,15-9,11-15,15-9) | Box score |
| Aug 29, 2000 | San Angelo, Texas | Angelo State Univ. 3, Midwestern St. 0 (15-6,15-6,15-5) | Box score |