| Date | Location | Result | |
| Nov 11, 2021 | Wichita Falls, Texas | Midwestern State 3, Cameron 0 (29-27,29-27,25-17) | Box score |
| Nov 06, 2021 | Wichita Falls, Texas | Ark.-Fort Smith 3, Midwestern State 2 (19-25,25-16,25-19,20-25,15-10) | Box score |
| Nov 05, 2021 | Wichita Falls, Texas | Okla. Christian 3, Midwestern State 0 (25-18,25-21,25-23) | Box score |
| Oct 30, 2021 | Austin, Texas | St. Edward's 3, Midwestern State 0 (25-11,25-22,25-21) | Box score |
| Oct 29, 2021 | San Antonio, Texas | St. Mary's (Texas) 3, Midwestern State 1 (25-19,25-20,19-25,25-14) | Box score |
| Oct 23, 2021 | Wichita Falls, Texas | Eastern NM 3, Midwestern State 1 (21-25,26-24,25-19,25-14) | Box score |
| Oct 22, 2021 | Wichita Falls, Texas | West Tex. A&M 3, Midwestern State 0 (25-14,25-12,25-18) | Box score |
| Oct 16, 2021 | Silver City, NM | Western N.M. 3, Midwestern State 1 (22-25,25-17,25-21,26-24) | Box score |
| Oct 08, 2021 | Wichita Falls, Texas | Tex. A&M-Commerce 3, Midwestern State 1 (20-25,25-15,25-21,25-21) | Box score |
| Oct 14, 2021 | Odessa, Texas | Tex. Permian Basin 3, Midwestern State 0 (25-15,25-22,28-26) | Box score |
| Oct 09, 2021 | Wichita Falls, Texas | Texas-Tyler 3, Midwestern State 1 (25-18,21-25,25-16,25-17) | Box score |
| Oct 02, 2021 | Denton, Texas | Texas Woman's 3, Midwestern State 2 (25-21,16-24,24-26,27-25,15-11) | Box score |
| Oct 01, 2021 | Dallas, Texas | DBU 3, Midwestern State 0 (25-22,24-17,25-23) | Box score |
| Sep 25, 2021 | Wichita Falls, Texas | Lubbock Christian 3, Midwestern State 1 (17-25,25-13,25-18,25-17) | Box score |
| Sep 24, 2021 | Wichita Falls, Texas | Angelo St. 3, Midwestern State 1 (25-22,22-25,25-16,25-16) | Box score |
| Sep 18, 2021 | Kingsville,Texas | A&M-Kingsville 3, Midwestern State 0 (25-17,26-24,25-20) | Box score |
| Sep 17, 2021 | Laredo, Texas | Midwestern State 3, Tex. A&M Int'l 2 (17-25,34-32,25-22,22-25,15-12) | Box score |
| Sep 11, 2021 | Wichita Falls, Texas | Midwestern State 3, Arkansas Tech 2 (18-25,19-25,25-13,25-21,15-13) | Box score |
| Sep 10, 2021 | Wichita Falls, Texas | Midwestern State 3, Eastern NM 0 (25-22,25-18,25-23) | Box score |
| Sep 10, 2021 | Wichita Falls, Texas | Colo. Mesa 3, Midwestern State 0 (25-17,25-17,25-17) | Box score |
| Sep 07, 2021 | Bethany, Okla. | Southern Nazarene 3, Midwestern State 1 (25-18,22-25,25-17,25-20) | Box score |
| Sep 04, 2021 | Golden, Colo. | Seattle Pacific 3, Midwestern State 1 (25-20,20-25,25-21,25-21) | Box score |
| Sep 04, 2021 | Golden, Colo. | Sioux Falls 3, Midwestern State 0 (25-18,25-20,25-16) | Box score |
| Sep 03, 2021 | Golden, Colo. | Colo. Sch. of Mines 3, Midwestern State 0 (25-11,25-14,26-24) | Box score |
| Sep 03, 2021 | Golden, Colo. | Colo. Christian 3, Midwestern State 1 (25-16,27-25,22-25,25-19) | Box score |