| Date | Location | Result | |
| 03/01/22 | Tyler, Texas | Texas-Tyler 55, Midwestern State 38 | Box score |
| 02/26/22 | Wichita Falls, Texas | Midwestern State 71, Okla. Christian 56 | Box score |
| 02/24/22 | Wichita Falls, Texas | Midwestern State 72, Ark.-Fort Smith 59 | Box score |
| 02/19/22 | Laredo, Texas | Tex. A&M Int'l 79, Midwestern State 53 | Box score |
| 02/17/22 | Kingsville, Texas | Tex. A&M-Kingsville 62, Midwestern State 57 | Box score |
| 02/10/22 | Wichita Falls, Texas | Midwestern State 70, Western NM 57 | Box score |
| 02/08/22 | Wichita Falls, Texas | Texas Woman's 84, Midwestern State 64 | Box score |
| 02/05/22 | Portales, NM | Midwestern State 79, Eastern N.M. 70 | Box score |
| 02/03/22 | Lubbock, Texas | Lubbock Christian 75, Midwestern State 64 | Box score |
| 01/29/22 | Wichita Falls, Texas | Cameron 81, Midwestern State 46 | Box score |
| 01/27/22 | Wichita Falls, Texas | Midwestern State 61, West Tex. A&M 49 | Box score |
| 01/23/22 | Commerce, Texas | Tex. A&M-Commerce 100, Midwestern State 68 | Box score |
| 01/20/22 | Denton, Texas | Midwestern State 83, Texas Woman's 76 | Box score |
| 01/15/22 | Odessa, Texas | Midwestern State 70, Tex. Permian Basin 58 | Box score |
| 01/13/22 | San Angelo, Texas | Angelo St. 98, Midwestern State 72 | Box score |
| 01/08/22 | Wichita Falls, Texas | Midwestern State 79, St. Mary's (TX) 73 | Box score |
| 01/06/22 | Wichita Falls, Texas | Midwestern State 72, St. Edward's 58 | Box score |
| 01/02/22 | Tyler, Texas | Texas-Tyler 86, Midwestern State 60 | Box score |
| 12/16/21 | Wichita Falls, Texas | Tex. A&M-Commerce 81, Midwestern State 35 | Box score |
| 12/13/21 | Wichita Falls, Texas | Texas-Tyler 55, Midwestern State 50 | Box score |
| 12/10/21 | Fort Smith, Ark. | Midwestern State 66, Ark.-Fort Smith 64 | Box score |
| 12/02/21 | Oklahoma City, Okla. | Midwestern State 71, Okla. Christian 68 | Box score |
| 11/28/21 | Wichita Falls, Texas | Midwestern State 79, Texas Wesleyan 72 | Box score |
| 11/23/21 | Shawnee, Okla. | Okla. Baptist 91, Midwestern State 70 | Box score |
| 11/16/21 | Lawton, Okla. | Cameron 91, Midwestern State 71 | Box score |
| 11/13/21 | Wichita Falls, Texas | Midwestern State 67, Adams St. 65 | Box score |
| 11/12/21 | Wichita Falls, Texas | Midwestern State 74, UC-Colo. Springs 63 | Box score |