| Date | Location | Result | |
| Nov 19, 2021 | Colorado Springs, Co | Colo. Sch. of Mines 3, Midwestern State 2 (OT) | Box score |
| Nov 09, 2021 | Wichita Falls, Texas | Texas AM-Commerce 3, Midwestern State 2 | Box score |
| Nov 06, 2021 | San Angelo, Texas | Midwestern State 2, Angelo State 1 (2OT) | Box score |
| Nov 03, 2021 | Wichita Falls, Texas | Midwestern State 2, Texas Woman's 1 (OT) | Box score |
| Oct 30, 2021 | Tyler, Texas | Midwestern State 2, UT Tyler 1 (2OT) | Box score |
| Oct 27, 2021 | Wichita Falls, Texas | Midwestern State 1, Lubbock Christian 0 | Box score |
| Oct 23, 2021 | Wichita Falls, Texas | Midwestern State 3, West Tex. A&M 2 | Box score |
| Oct 20, 2021 | Commerce, Texas | Midwestern State 1, Texas AM-Commerce 0 | Box score |
| Oct 16, 2021 | Wichita Falls, Texas | DBU 4, Midwestern State 2 | Box score |
| Oct 13, 2021 | Odessa, Texas | Midwestern State 5, Tex. Permian Basin 1 | Box score |
| Oct 09, 2021 | Wichita Falls, Texas | Tex. A&M Int'l 2, Midwestern State 2 (2OT) | Box score |
| Oct 06, 2021 | Oklahoma City, Okla. | Midwestern State 0, Okla. Christian 0 (2OT) | Box score |
| Oct 02, 2021 | San Antonio, Texas | Midwestern State 1, St. Mary's (Texas) 0 (OT) | Box score |
| Sep 29, 2021 | Wichita Falls, Texas | Midwestern State 3, Eastern N.M. 0 | Box score |
| Sep 25, 2021 | Wichita Falls, Texas | St. Edward's 1, Midwestern State 1 (2OT) | Box score |
| Sep 18, 2021 | Ada, Okla. | Midwestern State 1, East Central (Okla.) 0 (2OT) | Box score |
| Sep 12, 2021 | Wichita Falls, Texas | Midwestern State 3, Regis (Colo.) 1 | Box score |
| Sep 10, 2021 | Wichita Falls, Texas | Colo. Sch. of Mines 2, Midwestern State 0 | Box score |
| Sep 04, 2021 | Edmond, Okla. | Central Okla. 1, Midwestern State 0 | Box score |
| Sep 02, 2021 | Alva, Okla. | Midwestern State 3, Northwestern Okla. 0 | Box score |